| 產(chǎn)品編號 | bs-2252R |
| 英文名稱(chēng) | GABA Rabbit pAb |
| 中文名稱(chēng) | γ氨基丁酸抗體 |
| 別 名 | gamma-aminobutyric acid; gamma aminobutyric acid; 4 aminobutanoic acid; gamma amino butyric acid; γ－aminobutyric acid(GABA). |
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Specific References (2) | bs-2252R has been referenced in 2 publications.
[IF=5.25] Li-Min Zhang. et al. Subanesthetic dose of S-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of post-stroke chronic stress. J PSYCHIATR RES. 2023 Feb;158:1 IF ; Mouse.
[IF=1.28] Luo, Li, et al. "Niche astrocytes promote the survival, proliferation and neuronal differentiation of co?transplanted neural stem cells following ischemic stroke in rats." Experimental and Therapeutic Medicine. IF(IHC-P) ; Rat.
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| 產(chǎn)品類(lèi)型 | 小分子抗體 |
| 研究領(lǐng)域 | 免疫學(xué) 藥物及化合物 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | Rat (predicted: GABA) |
| 產(chǎn)品應用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 0.1031 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 細胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated GABA |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABA acts at inhibitory synapses in the brain and spinal cord. Inhibition is provoked by GABA binding resulting in hyperpolarization of the synaptic transmembrane potential of the affected neuron. GABA binding causes ion channels to open allowing either the flow of chloride or potassium ions into or out of the cell. γ-氨基丁酸（簡(jiǎn)稱(chēng)GABA）是一種天然存在的非蛋白質(zhì)氨基酸，是哺乳動(dòng)物中樞神經(jīng)系統中重要的抑制性神經(jīng)傳達物質(zhì)，約50%的中樞神經(jīng)突觸部位以GABA為遞質(zhì)。在人體大腦皮質(zhì)、海馬、丘腦、基底神經(jīng)節和小腦中起重要作用，并對機體的多種功能具有調節作用。當人體內GABA缺乏時(shí)，會(huì )產(chǎn)生焦慮、不安、疲倦、憂(yōu)慮等情緒，一般長(cháng)久處于高壓力族群如身處競爭環(huán)境中的人群、運動(dòng)員、上班族等，都很容易缺乏GABA需要及時(shí)補充以便舒緩情緒。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GABA) Polyclonal Antibody, Unconjugated (bs-2252R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GABA Polyclonal Antibody, Unconjugated(bs-2252R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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