| 產(chǎn)品編號 | bs-1061R-APC |
| 英文名稱(chēng) | Rabbit Anti-Myeloperoxidase/APC Conjugated antibody |
| 中文名稱(chēng) | APC標記的髓過(guò)氧化物酶抗體 |
| 別 名 | Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 激酶和磷酸酶 淋巴細胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, Rat, (predicted: Mouse, Dog, Cow, Horse, Rabbit, Guinea Pig, ) |
| 產(chǎn)品應用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Myeloperoxidase |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]. Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Subunit: Tetramer of two light chains and two heavy chains. Subcellular Location: Lysosome. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. Similarity: Belongs to the peroxidase family. XPO subfamily. Database links: Entrez Gene: 4353 Human Entrez Gene: 17523 Mouse Omim: 606989 Human SwissProt: P05164 Human SwissProt: P11247 Mouse Unigene: 458272 Human Unigene: 4668 Mouse Unigene: 47782 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 髓過(guò)氧化物酶MPO,作為一種白細胞酶,具有介導炎性反應、調節免疫應答等多種功能,并可參與疾病的發(fā)生發(fā)展過(guò)程。同時(shí),髓過(guò)氧化物酶基因存在基因多態(tài)性,也影響機體對疾病的易感性. 在正常淋巴組織中和各種髓樣細胞增生癥中，MPO均有較強表達，如：淋巴樣細胞、原核細胞、肥大細胞、漿細胞以及各種上皮源性腫瘤和肉瘤等。 |
