| 產(chǎn)品編號 | bs-12322R-Gold |
| 英文名稱(chēng) | Rabbit Anti-Protein BOC/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標記的蛋白BOC抗體 |
| 別 名 | Boc homolog (mouse); Brother of CDO; Protein BOC; brother of CDO precursor; Protein BOC; BOC_HUMAN. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 干細胞 細胞表面分子 細胞膜蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Horse, Zebrafish, Sheep, ) |
| 產(chǎn)品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Protein BOC |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: BOC is a receptor-like, single pass membrane protein belonging to the cell surface molecule subfamily of the Immunoglobulin/fibronectin type-III repeat family within the immunoglobulin superfamily. It contains three fibronectin type-III domains and four Immunoglobulin-like C2-type domains in its extracellular region. The intracellular region of BOC is not required for proper function. BOC localizes to the cell membrane and is ubiquitously expressed with highest expression levels in skeletal muscle and small intestine. Its mRNA expression is down-regulated by Ras. BOC is involved in accelerating myoblast differentiation and is dependent on CDO for its activity. BOC and CDO are co-expressed in muscle precursors and are components of a receptor complex that mediates cell-cell interactions important in myogenesis. Overexpression of BOC results in enhanced differentiation of myoblast cells. In addition, BOC is a target and signaling component of the Shh pathway. Function: Brother of CDO (BOC) interacts with Hedgehog (Hh) via a specific FNIII domain and belongs to the Ihog (interference hedgehog) family of proteins. Zebrafish BOC is expressed predominantly in the developing neural plate and later in the neural tube and developing brain. Subunit: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation. Subcellular Location: Cell membrane; Single pass type I membrane protein. Note: Enriched at sites of cell-cell contact. Tissue Specificity: Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa. Post-translational modifications: N-glycosylated. Similarity: Contains 3 fibronectin type-III domains. Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 100712740 Guinea pig Entrez Gene: 100071428 Horse Entrez Gene: 91653 Human Entrez Gene: 117606 Mouse Entrez Gene: 100347510 Rabbit Entrez Gene: 334628 Zebrafish Omim: 608708 Human SwissProt: Q9BWV1 Human SwissProt: Q6AZB0 Mouse Unigene: 591318 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
