| 產(chǎn)品編號 | bs-2625R |
| 英文名稱(chēng) | IL22BP Rabbit pAb |
| 中文名稱(chēng) | 白介素22受體結合蛋白抗體 |
| 別 名 | IL22RA2; Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Interleukin-22-binding protein; IL-22BP; IL22BP; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor class-II member 10; Cytokine receptor family type 2, soluble 1; CRF2-S1; ZcytoR16; I22R2_HUMAN. |
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Specific References (2) | bs-2625R has been referenced in 2 publications.
[IF=4.087] Wang, Xiaobai. et al. Relationship between IL-22 and IL-22BP in diabetic cognitive dysfunction. ACTA DIABETOL. 2023 Jan;:1-14 WB ; Mouse.
[IF=0] Almishri, Wagdi. Regulatory Immune-Responses Occurring within the Liver Downstream of Hepatic iNKTcell activation. Diss. University of Calgary, 2015. IHC-P ; Mouse.
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| 研究領(lǐng)域 | 免疫學(xué) 細胞表面分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | Mouse,Rat |
| 產(chǎn)品應用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 28(hu)/25(mo, ra kDa |
| 檢測分子量 | |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-22BP: 165-263/263 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
There are two isoforms of IL22 RA2 produce by alternative splicing. Isoform 1 may play a role in establishing and maintaining successful pregnancy. Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). It may play an important role as an IL22 antagonist in the regulation of inflammatory responses. Function: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy. Subcellular Location: Secreted. Tissue Specificity: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. Similarity: Belongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains. SWISS: Q969J5 Gene ID: 116379 Database links: Entrez Gene: 116379 Human Omim: 606648 Human SwissProt: Q969J5 Human Unigene: 126891 Human 白介素22結合蛋白是一種新型的Ⅱ類(lèi)細胞因子受體家族成員，它能直接結合IL－22，作為IL－22的拮抗劑，發(fā)揮著(zhù)多種生物學(xué)功能。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Spleen (Mouse) Lysate at 40 ug
Lane 2: Lymph node (Mouse) Lysate at 40 ug
Lane 3: Breast (Mouse) Lysate at 40 ug
Lane 4: Placenta (Mouse) Lysate at 40 ug
Lane 5: Skin (Mouse) Lysate at 40 ug
Lane 6: Spleen (Rat) Lysate at 40 ug
Lane 7: Lymph node (Rat) Lysate at 40 ug
Lane 8: Breast (Rat) Lysate at 40 ug
Lane 9: Skin (Rat) Lysate at 40 ug
Primary: Anti-IL22BP (bs-2625R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48/44/28 kD
Observed band size: 42 kD
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