| 產(chǎn)品編號 | bs-11091R |
| 英文名稱(chēng) | LSAMP Rabbit pAb |
| 中文名稱(chēng) | 大腦邊緣系統相關(guān)膜蛋白抗體 |
| 別 名 | IgLON family member 3; IGLON3; Lam; LAMP; Limbic system associated membrane protein; Limbic system associated membrane protein precursor; Limbic system-associated membrane protein; LSAMP; LSAMP_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 細胞粘附分子 細胞膜蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LSAMP: 51-150/338 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
LSAMP is a neuronal surface glycoprotein found in cortical and subcortical regions of the limbic system expressed on the surface of somata and proximal dendrites of neurons. It is a member of the immunoglobulin (Ig) superfamily and belongs to the IgLON subfamily of cell adhesion molecules. LSAMP contains three Ig domains and a glycosylphosphatidylinositol anchor. It is a highly conserved protein between rodents and humans (99% sequence identity) and it is involved in the regulation of neurite outgrowth and mediation of proper circuit formation of limbic pathways. This suggests that LSAMP plays an important role in the development and function of the limbic system. In addition, LSAMP may function as a tumor suppressor in renal carcinomas. Function: Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection. Subcellular Location: Cell membrane. Tissue Specificity: Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum. Similarity: Belongs to the immunoglobulin superfamily. IgLON family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q13449 Gene ID: 4045 Database links: Entrez Gene: 395687 Chicken Entrez Gene: 4045 Human Entrez Gene: 268890 Mouse Omim: 603241 Human SwissProt: Q98919 Chicken SwissProt: Q13449 Human SwissProt: Q8BLK3 Mouse Unigene: 26409 Human Unigene: 723683 Human Unigene: 310524 Mouse Unigene: 396840 Mouse Unigene: 473653 Mouse Unigene: 10176 Rat |
