| 產(chǎn)品編號 | bs-1195R-Bio |
| 英文名稱(chēng) | Rabbit Anti-beta endorphin/Biotin Conjugated antibody |
| 中文名稱(chēng) | 生物素標記的β-內啡肽/β endorphin抗體 |
| 別 名 | β-Endorphin; beta endorphin; βendorphin; beta endorfin; Beta endorphin; Corticotropin lipotropin; POMC; Proopiomelanocortin; COLI_HUMAN. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 內分泌病 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Mouse, (predicted: Human, Rat, Cow, Sheep, ) |
| 產(chǎn)品應用 | ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4.5kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human beta endorphin (237-267aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]. Function: ACTH stimulates the adrenal glands to release cortisol. MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin and Met-enkephalin are endogenous opiates. Subcellular Location: Secreted. Tissue Specificity: ACTH and MSH are produced by the pituitary gland. Post-translational modifications: Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N-acetylgalactosamine. DISEASE: Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Similarity: Belongs to the POMC family. Database links: Entrez Gene: 5443 Human Omim: 176830 Human SwissProt: P01189 Human Unigene: 1897 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 內啡肽是體內自己產(chǎn)生的一類(lèi)內源性的具有類(lèi)似嗎啡作用的肽類(lèi)物質(zhì)，是內啡肽(endogenous)和嗎啡(morphine)的縮些。 內啡肽（endorphin）具有嗎啡樣活性的神經(jīng)肽的總稱(chēng)亦稱(chēng)安多芬或腦內啡，是由腦垂體分泌的類(lèi)嗎啡生物化學(xué)合成物激素。它是由腦下垂體和脊椎動(dòng)物的丘腦下部所分泌的氨基化合物(肽) 。它能與嗎啡受體結合，產(chǎn)生跟嗎啡、鴉片劑一樣有止痛和欣快感。等同天然的鎮痛劑。利用藥物可增加腦內啡的分泌效果。 英文Endorphin是endomorphin的簡(jiǎn)化寫(xiě)法，endo有內在之含意，而morphin則為嗎啡的英文名稱(chēng)，故endorphin有大腦自我制造的類(lèi)嗎啡物質(zhì)之意。 內啡肽是體內自己產(chǎn)生的一類(lèi)內源性的具有類(lèi)似嗎啡作用肽類(lèi)物質(zhì)。是內源(endogenous)和嗎啡(morphine)的縮略詞。內啡肽可包括α-內啡肽、β-內啡肽、γ-內啡肽、蛋氨酸-腦啡肽、亮氨酸-腦啡肽、強啡肽A、強啡肽B等，都具有很強的類(lèi)嗎啡活性。蛋氨酸-腦啡肽的氨基酸序列為酪氨酸-甘氨酸-甘氨酸-苯丙氨酸-蛋氨酸。亮氨酸-腦啡肽第五個(gè)氨基酸不是蛋氨酸而是亮氨酸。α、β、γ-內啡肽分別為11肽、31肽、18肽，它們的前五個(gè)氨基酸序列與蛋氨酸-腦啡肽的五肽相同。這類(lèi)肽具有很強的生理功能。向動(dòng)物腦室中注射內啡肽，可引起全身深度失去痛覺(jué)，體溫下降，行為變得木僵。再施以嗎啡拮抗劑納洛酮(naloxone)，不再有上述失痛感覺(jué)。內啡肽誘導出的行為表明，這些肽可能參與感情應答的調節從垂體中分離出的內啡肽,其代表為β－內啡肽及鎮痛作用更強的強啡肽。它們都屬于內源性阿片肽，是機體抗痛系統的組成部分，具有生理意義。當機體有傷痛刺激時(shí)，內源性阿片肽被釋放出來(lái)以對抗疼痛。在內腓肽的激發(fā)下，人的身心處于輕松愉悅的狀態(tài)中，免疫系統實(shí)力得以強化，并能順利入夢(mèng)，消除失眠癥。 |
