| 產(chǎn)品編號 | bs-3541R-APC |
| 英文名稱(chēng) | Rabbit Anti-Pin1/APC Conjugated antibody |
| 中文名稱(chēng) | APC標記的肽基脯氨酞順?lè )串悩嬅窹inl抗體 |
| 別 名 | DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis/trans isomerase NIMA interacting; Pin 1; PPIase Pin1; Prolyl isomerase; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1; Protein NIMA interacting 1; Rotamase Pin1; UBL 5; UBL5; PIN1_HUMAN. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 神經(jīng)生物學(xué) 信號轉導 細胞凋亡 轉錄調節因子 激酶和磷酸酶 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Pin1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration. Function: Essential PPIase that regulates mitosis presumably byinteracting with NIMA and attenuating its mitosis-promotingactivity. Displays a preference for an acidic residue N-terminal tothe isomerized proline bond. Catalyzes pSer/Thr-Pro cis/transisomerizations. Down-regulates kinase activity of BTK. Cantransactivate multiple oncogenes and induce centrosomeamplification, chromosome instability and cell transformation.Required for the efficient dephosphorylation and recycling of RAF1after mitogen activation. Subunit: Interacts with STIL (By similarity). Interacts withKIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX.Interacts with BTK. Interacts (via PpiC domain) with DAPK1.Interacts with the phosphorylated form of RAF1. Interacts (via WWdomain) with ATCAY; upon NGF stimulation. Subcellular Location: Nucleus. Nucleus speckle. Cytoplasm.Note=Co-localizes with NEK6 in the nucleus. Mainly localized in thenucleus but phosphorylation at Ser-71 by DAPK1 results ininhibition of its nuclear localization. Tissue Specificity: The phosphorylated form at Ser-71 is expressedin normal breast tissue cells but not in breast cancer cells. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR.Phosphorylation at Ser-71 by DAPK1 results in inhibition of itscatalytic activity, nuclear localization, and its ability to inducecentrosome amplification, chromosome instability and celltransformation. Similarity: Contains 1 PpiC domain. Contains 1 WW domain. Database links: Entrez Gene: 5300 Human Entrez Gene: 23988 Mouse Omim: 601052 Human SwissProt: Q13526 Human SwissProt: Q9QUR7 Mouse Unigene: 465849 Human Unigene: 7906 Mouse Unigene: 6291 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肽基脯氨酞順?lè )串悩嬅窹inl，是調節細胞有絲分裂相關(guān)蛋白酶，對細胞周期運行起著(zhù)非常重要的調控作用。近年來(lái)研究表明，肽基脯氨酞順?lè )串悩嬅窹inl在多種腫瘤中過(guò)表達，是多個(gè)致癌信號通路的關(guān)鍵效應分子，可加強和催化多種致癌信號，使其無(wú)限放大，最終引起細胞轉化和增殖失控。因次，肽基脯氨酞順?lè )串悩嬅窹inl越來(lái)越引起人們關(guān)注，被稱(chēng)為腫瘤發(fā)生發(fā)展的催化分子。 近來(lái)該蛋白用于老年癡呆研究的也日漸增多。 |
