| 產(chǎn)品編號 | bs-0821R-APC |
| 英文名稱(chēng) | Rabbit Anti-laminin/APC Conjugated antibody |
| 中文名稱(chēng) | APC標記的層粘連蛋白抗體 |
| 別 名 | LAMA 1; LAMA; LAMA1; LAMB1; Laminin A chain; Laminin alpha 1; Laminin alpha 1 chain; Laminin B1 chain; Laminin subunit beta 1. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉導 細胞凋亡 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Cow, ) |
| 產(chǎn)品應用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 198kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human laminin |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies. Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Subcellular Location: Secreted > extracellular space > extracellular matrix > basement membrane. Tissue Specificity: Broadly expressed in: skin, heart, lung, and the reproductive tracts. Similarity: Contains 11 laminin EGF-like domains. Contains 1 laminin IV type A domain. Contains 1 laminin N-terminal domain. Database links: Entrez Gene: 10319 Human Entrez Gene: 284217 Human Entrez Gene: 3908 Human Entrez Gene: 3912 Human Entrez Gene: 3913 Human Entrez Gene: 3915 Human Entrez Gene: 3918 Human Entrez Gene: 16772 Mouse Omim: 150320 Human SwissProt: P07942 Human SwissProt: P24043 Human SwissProt: P25391 Human SwissProt: P55268 Human SwissProt: Q9Y6N6 Human SwissProt: P19137 Mouse SwissProt: Q9R0B6 Mouse Unigene: 201805 Human Unigene: 270364 Human Unigene: 302362 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 層粘連蛋白主要存在于基膜(basal lamina)結構中，是基膜所特有的非膠原糖蛋白。 層粘連蛋白在細胞發(fā)育過(guò)程中刺激細胞粘著(zhù)、細胞運動(dòng)。LN能夠刺激胚胎中神經(jīng)軸的生長(cháng),并促進(jìn)成年動(dòng)物的神經(jīng)損傷后重生長(cháng)和再生。如同纖粘連蛋白,細胞外的LN能夠影響細胞的生長(cháng)、遷移和分化。LN在原生殖細胞的遷移中起關(guān)鍵作用。 層粘連蛋白是細胞外基底膜的主要組成部分，分布于基底膜和細胞外基質(zhì)內、成纖維細胞、內皮細胞和平滑肌細胞分泌層粘連蛋白。腫瘤的浸潤和轉移與其遭到破壞相關(guān)。該抗體可用于標記基底膜，有助于觀(guān)察腫瘤周?chē)啄さ姆植技捌涓淖?，間接提示該腫瘤的分化程度和浸潤情況。 |
