| 產(chǎn)品編號 | bs-0071R-Gold |
| 英文名稱(chēng) | Rabbit Anti-Neuropeptide Y/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標記的神經(jīng)肽Y抗體 |
| 別 名 | Neuropeptide tyrosine; Neuropeptide Y precursor; NPY; PYY 4; PYY4; Y Neuropeptide; Pro-neuropeptide Y; NPY_HUMAN. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 心血管 信號轉導 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Cow, Horse, Rabbit, ) |
| 產(chǎn)品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4/8kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NPY |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Subcellular Location: Secreted. Tissue Specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. Post-translational modifications: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Similarity: Belongs to the NPY family. Database links: Entrez Gene: 396464 Chicken Entrez Gene: 4852 Human Entrez Gene: 109648 Mouse Omim: 162640 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白 神經(jīng)肽Y是一種神經(jīng)傳導因子，參與機體的應急反應， 在應激狀態(tài)下-NPY升高;他還可以促進(jìn)血小板聚集、白細胞粘附及 巨噬細胞活化而參 與免疫反應 神經(jīng)肽Y廣泛分布于動(dòng)物中樞和外周神經(jīng)元及機體組織、器官和腺體內 ,影響動(dòng)物采食、激素分泌、心血管效應、調節體溫、生物節律、性行為及動(dòng)物情緒等多種功能。 由于結構中富含酪氨酸 ,故稱(chēng)為神經(jīng)肽酪氨酸 (NPY)。它的結構與同是 36個(gè)氨基酸的胰多肽 (pp)和肽 YY(PYY)極其相似 ,故認為同屬胰多肽家族。從分子結構看 ,人、大鼠、豚鼠和兔序列安全一致 ,而牛、羊、豬 NPY序列與人的序列只相差一個(gè)氨基酸。 |
