| 產(chǎn)品編號 | bs-15510R-Gold |
| 英文名稱(chēng) | Rabbit Anti-TRP1/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標記的酪氨酸酶相關(guān)蛋白1抗體 |
| 別 名 | 5; 6-dihydroxyindole-2-carboxylic acid oxidase; CAS2; Catalase B; CATB; DHICA oxidase; Glycoprotein 75; GP75; Melanoma antigen gp75; TRP; TRP-1; TRP1; Tyrosinase related protein 1; Tyrosinase-related protein 1; TYRP; TYRP1; TYRP1_HUMAN; TYRRP. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 細胞生物 染色質(zhì)和核信號 細胞類(lèi)型標志物 表觀(guān)遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Cow, Horse, ) |
| 產(chǎn)品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tyrosinase-related protein 1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: TRP1 is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. Function: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Subcellular Location: Melanosome membrane; Single-pass type I membrane protein (By similarity). Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity). Tissue Specificity: Pigment cells. DISEASE: Albinism oculocutaneous 3 (OCA3) [MIM:203290]: An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the tyrosinase family. Database links: Entrez Gene: 7306 Human Entrez Gene: 22178 Mouse Omim: 115501 Human SwissProt: P17643 Human SwissProt: P07147 Mouse Unigene: 270279 Human Unigene: 30438 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
