| 產(chǎn)品編號 | bs-19341R-AP |
| 英文名稱(chēng) | Rabbit Anti-NRAMP1/AP Conjugated antibody |
| 中文名稱(chēng) | 堿性磷酸酶（AP）標記的自然抗性相關(guān)巨噬細胞蛋白1抗體 |
| 別 名 | LSH; Natural resistance associated macrophage protein 1; Natural resistance-associated macrophage protein 1; NRAM1_HUMAN; NRAMP 1; NRAMP; PBC; SLC11A1; Solute carrier family 11 (proton coupled divalent metal ion transporters) member 1; solute carrier family 11 (sodium/phosphate symporters) member 1; Solute carrier family 11 member 1. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 信號轉導 細胞膜蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | (predicted: Human, Rat, Cow, Rabbit, ) |
| 產(chǎn)品應用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NRAMP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] Function: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Subcellular Location: Membrane. Tissue Specificity: Macrophages; peripheral blood leukocytes, lung, spleen and liver. Similarity: Belongs to the NRAMP family. Database links: Entrez Gene: 6556 Human Entrez Gene: 18173 Mouse Omim: 600266 Human SwissProt: P49279 Human SwissProt: P41251 Mouse Unigene: 591607 Human Unigene: 2913 Mouse Unigene: 105919 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
