| 產(chǎn)品編號 | bs-23146R-APC |
| 英文名稱(chēng) | Rabbit Anti-ASBT/SLC10A2/APC Conjugated antibody |
| 中文名稱(chēng) | APC標記的頂膜鈉依賴(lài)性膽鹽轉運體蛋白抗體 |
| 別 名 | SLC10A2; Apical sodium dependent bile acid transporter; Apical sodium- dependent bile acid transporter; IBAT; ileal apical sodium-dependent bile acid transporter; Ileal sodium dependent bile acid transporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBT; Na+ bile acid cotransporter; Na+ dependent ileal bile acid transporter; NTCP2; Sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family); Solute carrier family 10 member 2. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號轉導 通道蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Mouse, (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ASBT/SLC10A2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: SLC10A2 plays a critical role in reabsorption of bile acids from the the small intestine lumen. Passive flow of sodium ions down their concentration gradient is coupled to bile acid movement, resulting in an increase in the concentration of bile acids in the interior of the cell. This action conserves the body's pool of re-circulating bile acid. SLC10A2 also plays a key role in cholesterol metabolism as cholesterol is the precursor molecule in bile acid synthesis mediated by CYP7A and FXR. Function: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Subunit: Monomer and homodimer. Subcellular Location: Membrane; Multi-pass membrane protein. DISEASE: Primary bile acid malabsorption (PBAM) [MIM:613291]: An intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids. {ECO:0000269|PubMed:9109432}. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Database links: Entrez Gene: 6555 Human Entrez Gene: 20494 Mouse Omim: 601295 Human SwissProt: Q12908 Human SwissProt: P70172 Mouse Unigene: 194783 Human Unigene: 3500 Mouse Unigene: 85891 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
